603 papers
This study identifies a novel mechanosensitive PIEZO1-ANGPT2-ITGA9 signaling loop in Schlemm's canal endothelium that regulates intraocular pressure, revealing that disruption of this pathway leads to glaucoma and highlighting it as a promising therapeutic target.
This study demonstrates that cardiac REDD1 promotes glucose oxidation and hypertrophic growth by suppressing PPARα activity and its downstream targets (such as PDK4) through an mTORC1-independent mechanism.
The paper introduces CytoType and its simplified variant ESM-CE, species-specific models that leverage pre-trained protein embeddings to achieve cell type classification performance comparable to large foundation models while using orders of magnitude fewer parameters and offering greater interpretability.
The paper introduces EpiFlow, a robust, high-throughput spectral flow cytometry platform capable of simultaneously quantifying 16 epigenetic markers at single-cell resolution across diverse species and biological contexts, enabling precise cell-type classification and drug effect analysis.
This study provides a comprehensive molecular characterization of ATDC5-derived cartilage organoids through time-resolved transcriptomic and proteomic analyses, revealing a detailed profile of chondrogenic differentiation and previously unreported extracellular matrix components to enhance the model's utility for studying human genetic skeletal diseases.
This study reveals that Greatwall kinase drives acute myeloid leukemia cell proliferation through a non-canonical mechanism involving the direct phosphorylation of MARK3 to regulate cytokinesis, rather than the previously established ENSA-PP2A-B55 pathway.
This study demonstrates that repeated administration of mesenchymal stromal cells (MSCs) during ex vivo lung perfusion and the early post-transplant period, rather than a single dose or the specific cell source, effectively restores function and prevents graft dysfunction in severely injured porcine donor lungs, offering a promising regenerative strategy to expand the organ pool for transplantation.
This study demonstrates that Huh7 cells cultured in physiologically relevant media exhibit metabolic responses and lipid accumulation patterns comparable to primary human hepatocytes, supporting their utility as a scalable in vitro model for studying metabolic dysfunction-associated steatotic liver disease (MASLD).
This study demonstrates that the histone acetyltransferase HAT1 is essential for maintaining intestinal stem cell homeostasis by regulating chromatin structure in lamina-associated domains to control stem cell proliferation and differentiation.
This study reveals that cardiomyocyte autophagy, regulated by AP-1 transcription factors, is essential for driving heart regeneration in adult zebrafish by facilitating cardiomyocyte protrusion into injured tissue and modulating macrophage phenotypes from pro-inflammatory to pro-angiogenic and pro-fibrotic states to ensure effective scar resolution.